The definition of rate of reaction is the change in concentration of products over the change in time (∆[P] / ∆t). General Mechanism for an acidic catalyst. This might explain the large data spread. The partner’s yield, as seen in Table 2, was 59.0 %. ? Synthesis of Aspirin By: Jon Torre Purpose: To determine which of four catalysts yields the fastest reaction rate in the acetylation of salicylic acid (1) to form acetylsalicylic acid (2). The contents of each tube and 50 mL distilled water were then added to a 125 mL Erlenmeyer flask. ? Compound A was determined to be pure acetylsalicylic acid because it underwent no color change and thus contained no phenol groups. The factors that contributed to the inaccuracy of the experiment are the following: Reflux: The apparatus used in the experiment were quite old. However compared to the theoretical yield it is evident that there was a great loss of aspirin that should have been formed. The report also mentions how there are factors in the production of aspirin and how they affect the yield and purity. The experiment starts by combining such chemicals such as salicylic acid and acetic anhydride. Distilled water ? The chemical equation for the synthesis of aspirin is C7H6O3 + C4H6O3 –> C9H8O4 +C2H4O2, which is a reaction of salicylic acid with acetic anhydride in the presence of phosphoric acid. The procedure was repeated using one drop of molecular iodine solution in place of iron (III) chloride solution. Packaging (in industry) Conclusion and Recommendations Overall the experiment was a success, considering the flaws in the experiment such as the apparatus and time. Therefore moles acetylsalicylic acid (aspirin) = 0. Balance ? Enthalpies of other side reactions, such as the polymerization of salicylic acid may have also contributed to the temperature change, corrupting the data. As can be seen from Table 1, sulfuric acid best increased the reaction rate of the catalysts because the temperature of the sulfuric acid-catalyzed reaction rose 4 ˚C in only 5.5 s. Therefore, sulfuric acid was the most effective catalyst, followed by boron trifluoride etherate, pyridine, then sodium acetate. A small amount of a strong acid is used as a catalyst that speeds up the reaction. Acids, unlike bases, catalyze the reaction at multiple steps because the acid’s proton is transferred around the molecule. A/AS level. Shake the mixture very well. ? Procedure and Experimental Technique: Method of Production of Aspirin: ? If the experiment was to be done again the following recommendations would be given: ? If you need this or any other sample, we can send it to you via email. The reactants: In the experiment that was carried out the reactants were not measured by the apprentices. 6g of aspirin was attained. Will 5G Impact Our Cell Phone Plans (or Our Health?! How a warehouse of ammonium nitrate destroyed a capital city. This proves that the aspirin that had been made in the experiment was not 100% pure and contained some impurities. the quality of the equipment used ? As soon as a reactant is consumed the reaction will stop, no matter how much of the other reactants remaining. Only the salicylate ion complexes to iron(III). Salicylic acid, whose name comes from Salix, the willow family of plants, was derived from, To prepare aspirin, salicylic acid is reacted with an excess of acetic, anhydride. equation). As soon as this occurs note the temperature. Using these ideas it will be deduced as how the temperature of water affects the solubility of the Aspirin. J. Data: ? com/lifescience/phar/ACETYLSALICYLIC%20ACID.