Pharmaceutically, it is used as a sympathomimetic by injection for treating emergencies such as shock. I have allergies that make my sinuses swell shut, and its very painful. A randomized double-blinded comparison of phenylephrine and ephedrine infusion combinations to maintain blood pressure during spinal anesthesia for cesarean delivery: The effects on fetal acid-base status and hemodynamic control. There is a lot of information about the apparent safety hazards of synephrine, which compare synephrine to ephedrine. Unlike Ephedra, which may cause serious side effects, the consumption of Synephrine is generally safe. It is able to stimulate brain, increase heart rate, constrict blood vessels, and expand bronchial tubes. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Preload dependency determines the effects of phenylephrine on cardiac output in anaesthetised patients: A prospective observational study. Since the ban on ephedrine, people have been looking for a natural metabolic stimulant without negative side effects. For Nasal Congestion: I have read so much about this medication not working. We take pride in our user’s ratings and strive to create an open and transparent commercial environment where our customers are guaranteed to get the service that they deserve. The effects of Synephrine are quite immediate, coming up within five minutes following the injection, and last for about an hour. The authors also give special thanks to Eva Maria Rolf Jensen (nurse) at Aarhus University Hospital/Aarhus University for her support throughout the study. There may be variations in CSA schedules between individual states. Did it help? An old article on ephedrine Vs syneprine By Alan E. Shugarman, MS, RD This information was published in Flex Magazine, October 1999 issue, in the Advanced Nutrition section. In the present study, peritumoral positron emission tomography parameters were not normalized to those of a corresponding contralateral region. Compare Ephedrine vs Phenylephrine head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. If I take 2 10mg to start my day, I'm in good shape with the regular dose the rest of the day. ), Aarhus University Hospital, Aarhus, Denmark; Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark (I.K.M., L.Ø. There isn't much comparison I'd say, ephedrine acts at your CNS (brain) and is thus stimulatory, inhibits appetite and gives you the feeling of "energy", whereas syndphrine has all the effects of ephedrine minus the effects in the brain. In extreme cases, the consumption of Ephedra may lead to heart attack, stroke, or death. Ephedrine products are now banned in the United States. As a dietary supplement, Ephedra is often used to enhance athletic performance. All I have seen is that it's a placebo. For more information relating to the safety of synephrine, see our article here. Through years of research, development and learning to understand the market, we have created what we believe to be the ultimate store of high quality dietary supplements and cutting-edge brain-boosters. See the full Pregnancy Warnings document. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. We looked into the sources of many of these claims and found studies examining mostly ‘synephrine-based’ supplements. What is Synephrine? All I have seen is that it's a placebo. May also be prescribed off label for Narcolepsy, Adams-Stokes Syndrome, Myasthenia Gravis, COPD - Acute. I know that Synephrine works through some of the same mechanisms as Ephedrine, and that Synephrine is a much weaker compound compared to the latter. Adverse Effects of Ephedra We at are a team of professionals from a variety of backgrounds, dedicated to the mission of providing the highest quality and highest purity nutritional health supplements on the market. [2] Ephedrine,, retrieved June 21, 2016, [3] Stohs SJ, Preuss HG, Shara M. A Review of the Human Clinical Studies Involving Citrus aurantium (Bitter Orange) Extract and its Primary Protoalkaloid p-Synephrine. Synephrine vs Ephedrine: Safety There is a lot of information on the internet relating to the safety of synephrine compared to ephedrine. But I don't suffer from a runny nose or congestion exactly. Synephrine is generally safer to consume. On the other hand, Synephrine is an alkaloid that naturally occurs in several plants and animals. External carotid artery flow maintains near infrared spectroscopy-determined frontal lobe oxygenation during ephedrine administration. Other than good old benadryl, there is no other medication that is even slightly effective for me. ( Log Out /  Once upon waking and once in the afternoon seems to get me going with addition to a cup of coffee. However, it has still been found to be very effective, and doesn’t appear to produce negative health effects![3]. This work was supported by the Lundbeck Foundation (ref. The authors also thank the patients for their time and patience and the following people at the Department of Nuclear Medicine and PET Center at Aarhus University Hospital: Birthe Hedegaard Jensen (Research Coordinator), Rikke Birkegård Bertelsen (Medical Laboratory Technologist), Mie Ringgaard Dollerup (Medical Laboratory Technologist), and Per Borghammer (Professor, M.D., Ph.D., DMSc). However, the peritumoral region of interest is composed of both gray and white matter. View side-by-side comparisons of medication uses, ratings, cost, side effects, interactions and more. There may be variations in CSA schedules between individual states. The pros are it works similarly to the typical narcoleptic drug. We look specifically for the latest and most promising research in the fields of cognition enhancement, neuroscience and alternative health supplements, and develop commercial strategies to bring these technologies to the marketplace. May also be prescribed off label for Narcolepsy, Adams-Stokes Syndrome, Myasthenia Gravis, COPD - Acute. ( Log Out /,, Synephrine vs Ephedrine: What You Need to Know, 20 Things Most People Learn Too Late In Life, The World Has Just Witnessed A “Pearl Harbor Moment” In Armenia. However, synephrine is considered much safer for use than ephedrine.[1]. The adrenergic effects are increased cognition and power and overall body performance because of an adrenaline rush. Cerebral metabolic rate of oxygen changes in the peritumoral and contralateral regions of interest were similar between ephedrine- and phenylephrine-treated patients. Is White America Really Ready to Reject Trump’s Fascism? I've found phenylephrine has helped in a variable increased dose. Automatic 3-D model-based neuroanatomical segmentation. These findings correspond to similar ICP and cerebral perfusion pressure measurements in patients undergoing craniotomy and appeared to be too low to be associated with intraoperative brain swelling.1  Thus, the impact of ICP on cerebral blood flow and cerebral metabolic rate of oxygen measurements was probably limited, but an effect cannot be excluded. Neroli oil and petitgrain oil, which are used in the fragrance and food industries, are extracted from the bitter orange fruit. In particular, the cases that resulted in death mostly involve Ephedra supplements that contain ephedrine. Such effects do not occur at low doses. However, when choosing between Synephrinevs Ephedra, one should understand that Synephrine has much less adverse side effects. Required fields are marked *. Possible extracranial contamination of the regional cerebral oxygen saturation signal and absence of bilateral BIS and near-infrared spectroscopy measurements and thus comparison of both hemispheres are additional weaknesses of the study.48,49. Cerebral [15O]water clearance in humans determined by PET: I. My heart rate jumped but my blood pressure dropped like a rock - from 145/95 to 85/50 within thirty seconds. ( Log Out /  The primary reason why people consider Synephrine vs Ephedra is that Ephedra comes with a number of side effects. I had a severe allergic reaction to something and was in the ambulance when I was given epinephrine intravenously after Benadryl failed to slow the reaction. Your email address will not be published. The role of the microcirculation in delayed cerebral ischemia and chronic degenerative changes after subarachnoid hemorrhage. This does not necessarily mean no interactions exist. Is cerebral oxygenation negatively affected by infusion of norepinephrine in healthy subjects? But such effects are not very dramatic. Effects of Synephrine Ephedrine, but not phenylephrine, increases bispectral index values during combined general and epidural anesthesia. Save my name, email, and website in this browser for the next time I comment. Ephedra contains various alkaloid and non-alkaloid compounds with stimulant and thermogenic effects. For pharmaceutical purposes, it is rarely consumed by mouth for treating hay fever and asthma. I'm reffering to it's capabilities of increasing metabolic rate and reducing fat mass. Sudafed PE Children's Nasal Decongestant. Effects of vasopressors on cerebral circulation and oxygenation: A narrative review of pharmacodynamics in health and traumatic brain injury. Full protocol available at: Address correspondence to Dr. Koch: Department of Anesthesiology, Section of Neuroanesthesia, Aarhus University Hospital, 8000 Aarhus C, Denmark. ** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. See the full phenylephrine side effects document. In both groups and regions of interest, pretreatment oxygen extraction fraction was in the range from 52% to 65%, which is higher than values of approximately 30% to 50% in selected brain regions normally reported in awake healthy subjects.47  This observation is likely explained by reduction in cerebral blood flow. Ephedra is widely known for the great stimulant and thermogenic effects, and thus often used for various traditional treatments and performance enhancement purposes.